Birth defects are conditions present at birth that affect the structure or function of one or more body parts or systems and can influence health, development, and life expectancy. Effects of birth defects can range from mild to severe. Causes of most birth defects are unknown. From 2017 to 2021, there were 28,151 babies born with a birth defect in Florida; this represents a rate of 259.6 births per 10,000 live births. Some of the more common birth defects include atrial or ventricular septal defects, critical congenital heart defects, Down Syndrome, hypospadias, and clubfoot.